Ro 19-4603

Name: Ro 19-4603
Brand: Tocris Bioscience
SKU: 1995

Tocris Bioscience, part of Bio-Techne | Catalog # 1995

COA / SDS

Benzodiazepine inverse agonist

Discontinued Product

1995 has been discontinued. View all Benzodiazepine Inverse Agonists products.

Key Product Details

Description:	Benzodiazepine inverse agonist
Chemical Name:	5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	319.38

View Full Technical Details for Ro 19-4603

Technical Data
Citations

Biological Activity for Ro 19-4603

Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA_A receptors (K_i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.

Technical Data for Ro 19-4603

M. Wt	319.38
Formula	C₁₅H₁₇N₃O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	99632-94-7
PubChem ID	127382
InChi Key	ZIGMMUKDYCABPW-UHFFFAOYSA-N
Smiles	CN1CC2=C(N=CN2C2=C(SC=C2)C1=O)C(=O)OC(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ro 19-4603

References are publications that support the biological activity of the product.

June Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. J.Pharmacol.Exp.Ther. 1995 PMID: 7562476
June The novel benzodiazepine inverse agonist RO19-4603 antagonises ethanol motivated behaviours: neuropharmacological studies. Brain Res. 1998 PMID: 9518641
Wong and Skolnick High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 1992 PMID: 1311690

Ro 19-4603

Tocris Bioscience, part of Bio-Techne | Catalog # 1995

Key Product Details

Biological Activity for Ro 19-4603

Technical Data for Ro 19-4603

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ro 19-4603

Product Documents for Ro 19-4603

COA

Certificate of Analysis

SDS

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