RN 1 dihydrochloride

Name: RN 1 dihydrochloride
Brand: Tocris Bioscience
SKU: 4977

Tocris Bioscience, part of Bio-Techne | Catalog # 4977

Citations (2)

COA / SDS

LSD1 inhibitor

Key Product Details

Description:	LSD1 inhibitor
Chemical Name:	1-(4-methyl-1-piperazinyl)-2-[[(1R,2S)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	452.42

View Full Technical Details for RN 1 dihydrochloride

Technical Data
Citations

Biological Activity for RN 1 dihydrochloride

RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Compound Libraries for RN 1 dihydrochloride

RN 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for RN 1 dihydrochloride

M. Wt	452.42
Formula	C₂₃H₂₉N₃O₂.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1781835-13-9
PubChem ID	90488995
InChi Key	WMHAFZOOUBPQRX-VSIGASKDSA-N
Smiles	O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 1 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.05	20
	DMSO	9.05	20 with gentle warming

Preparing Stock Solutions for RN 1 dihydrochloride

The following data is based on the product molecular weight 452.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.05 mL	55.26 mL	110.52 mL
1 mM	2.21 mL	11.05 mL	22.10 mL
2 mM	1.11 mL	5.53 mL	11.05 mL
10 mM	0.22 mL	1.11 mL	2.21 mL

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Reconstitution Calculator

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References for RN 1 dihydrochloride

References are publications that support the biological activity of the product.

Neelamegam Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 2012 PMID: 22754608