RIPK2 inhibitor 1

Name: RIPK2 inhibitor 1
Brand: Tocris Bioscience
SKU: 6603

Tocris Bioscience, part of Bio-Techne | Catalog # 6603

COA / SDS

Potent RIPK2 inhibitor

Key Product Details

Description:	Potent RIPK2 inhibitor
Chemical Name:	3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	410.48

View Full Technical Details for RIPK2 inhibitor 1

Technical Data
Citations

Biological Activity for RIPK2 inhibitor 1

RIPK2 inhibitor 1 is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC₅₀ of 5-10 nM). It inhibits NF-κB activity and decreases cancer cell proliferation by 70%. In vivo, RIPK2 inhibitor 1 inhibits intestinal and lung inflammation with low toxicity in rodent models.

Technical Data for RIPK2 inhibitor 1

M. Wt	410.48
Formula	C₂₅H₂₂N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1290490-78-6
PubChem ID	99506096
InChi Key	OIIYBZHRYXJCHR-UHFFFAOYSA-N
Smiles	CN1C=CN=C1C2=CC(NC(C3=CC(NC(C4=CC=CC=C4)=O)=C(C)C=C3)=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RIPK2 inhibitor 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.05	100

Preparing Stock Solutions for RIPK2 inhibitor 1

The following data is based on the product molecular weight 410.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for RIPK2 inhibitor 1

References are publications that support the biological activity of the product.

Salla Identification and characterization of novel receptor-interacting serine/threonine-protein kinase 2 inhibitors using structural similarity analysis. J.Pharmacol.Exp.Ther. 2018 PMID: 29555876