RIPGBM

Name: RIPGBM
Brand: Tocris Bioscience
SKU: 6892

Tocris Bioscience, part of Bio-Techne | Catalog # 6892

COA / SDS

RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant

Key Product Details

Description:	RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
Chemical Name:	N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	428.46

View Full Technical Details for RIPGBM

Technical Data
Citations

Biological Activity for RIPGBM

RIPGBM is a RIPK2 modulator, pro-drug of cRIPGM. cRIPGM binds RIPK2 (apparent K_d = 2.3 μM). Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC₅₀ is <500 nM). Five-fold selective for CSCs compared with control cell types. Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. Inhibits tumor formation and growth in vivo. Orally bioavailable and brain penetrant.

Technical Data for RIPGBM

M. Wt	428.46
Formula	C₂₆H₂₁FN₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	355406-76-7
InChi Key	COATXBHZYVUJQP-UHFFFAOYSA-N
Smiles	CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RIPGBM

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.28	10

Preparing Stock Solutions for RIPGBM

The following data is based on the product molecular weight 428.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.70 mL	233.39 mL
0.5 mM	4.67 mL	23.34 mL	46.68 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

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References for RIPGBM

References are publications that support the biological activity of the product.

Lucki A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc.Natl.Acad.Sci.USA. 2019 PMID: 30846550