Riluzole hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0768
GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
Key Product Details
Description
GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
Product Description
Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.Product Specifications
Molecular Weight
270.66
Formula
C8H5F3N2OS.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
CAS Number
850608-87-6]
PubChem ID
6419992
InChI Key
QEAOELIJQRYJJS-UHFFFAOYSA-N
SMILES
Cl.NC1=NC2=CC=C(OC(F)(F)F)C=C2S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.71 | 10 with gentle warming | |
| DMSO | 27.07 | 100 |
Preparing Stock Solutions
for Riluzole hydrochloride
The following data is based on the product molecular weight 270.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.47 mL | 36.95 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.39 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Richter Riluzole activates TRPC5 channels independently of PLC activity. Br.J.Pharmacol. 2014 PMID: 24117252
- Umeniya and Berger Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 1995 PMID: 8719800
- Song Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 1997 PMID: 9262334
- Taylor and Meldrum Na+ channels as targets for neuroprotective drugs. TiPS 1995 PMID: 7482996
- Fumagalli Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 2008 PMID: 18036519
Product Specific Notices for Riluzole hydrochloride
For research use only
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