Ribociclib
Tocris Bioscience, part of Bio-Techne | Catalog # 7050
Dual cdk4/cdk6 inhibitor; orally bioavailable
Key Product Details
Description
Dual cdk4/cdk6 inhibitor; orally bioavailable
Alternative Names
LEE-011
Product Description
Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.Product Specifications
Molecular Weight
434.54
Formula
C23H30N8O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS Number
1211441-98-3
PubChem ID
44631912
InChI Key
RHXHGRAEPCAFML-UHFFFAOYSA-N
SMILES
CN(C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.35 | 10 |
Preparing Stock Solutions
for Ribociclib
The following data is based on the product molecular weight 434.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.01 mL | 115.06 mL | 230.13 mL |
| 0.5 mM | 4.60 mL | 23.01 mL | 46.03 mL |
| 1 mM | 2.30 mL | 11.51 mL | 23.01 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rader Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 2013 PMID: 24045179
Product Specific Notices for Ribociclib
For research use only
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