RHC 80267

Name: RHC 80267
Brand: Tocris Bioscience
SKU: 1842

Tocris Bioscience, part of Bio-Techne | Catalog # 1842

Citations (11)

COA / SDS

Diacylglycerol lipase inhibitor

Key Product Details

Description:	Diacylglycerol lipase inhibitor
Alternative Names:	U 57908
Chemical Name:	O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone
Purity:	≥95% (HPLC)
Molecular Weight:	394.51

View Full Technical Details for RHC 80267

Technical Data
Citations

Biological Activity for RHC 80267

RHC 80267 is an inhibitor of diacylglycerol lipase (IC₅₀ values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A₂. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC₅₀ = 4 μM).

Technical Data for RHC 80267

M. Wt	394.51
Formula	C₂₀H₃₄N₄O₄
Storage	Store at +4°C
Purity	≥95% (HPLC)
CAS Number	83654-05-1
PubChem ID	5063
InChi Key	RXSVYGIGWRDVQC-UHFFFAOYSA-N
Smiles	O=C(NCCCCCCNC(O/N=C2\CCCCC2)=O)O/N=C1CCCCC/1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RHC 80267

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.45	100
	ethanol	39.45	100

Preparing Stock Solutions for RHC 80267

The following data is based on the product molecular weight 394.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.67 mL	25.35 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for RHC 80267

References are publications that support the biological activity of the product.

Sutherland and Amin Relative activities of rat and dog platelet phospholipase A₂ and diglyceride lipase. J.Biol.Chem. 1982 PMID: 7142192
Suzuki Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res. 2002 PMID: 12713022
Ghisdal The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol. 2005 PMID: 15958263