RGDS peptide
Tocris Bioscience, part of Bio-Techne | Catalog # 3498
Integrin binding sequence; inhibits integrin receptor function
Key Product Details
Description
Integrin binding sequence; inhibits integrin receptor function
Product Description
RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.Product Specifications
Molecular Weight
433.42
Formula
C15H27N7O8
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
91037-65-9
PubChem ID
107775
InChI Key
NNRFRJQMBSBXGO-CIUDSAMLSA-N
SMILES
[H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
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Background References
References are publications that support the biological activity of the product.
- Moon Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 2009 PMID: 19272161
- Droppelmann Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 2009 PMID: 19276073
- Grigoriou Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 2005 PMID: 15522882
Product Specific Notices for RGDS peptide
For research use only
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