Repaglinide

Name: Repaglinide
Brand: Tocris Bioscience
SKU: 3805

Tocris Bioscience, part of Bio-Techne | Catalog # 3805

Citations (5)

COA / SDS

Kir6 (KATP) channel blocker

Key Product Details

Description:	K_ir6 (K_ATP) channel blocker
Alternative Names:	AG-EE 623ZW
Chemical Name:	2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	452.59

View Full Technical Details for Repaglinide

Technical Data
Citations

Biological Activity for Repaglinide

Repaglinide is a K_ir6 (K_ATP) channel blocker that binds with high affinity for SUR1 when co-expressed with K_ir6.2 (K_d = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

Compound Libraries for Repaglinide

Repaglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Repaglinide

M. Wt	452.59
Formula	C₂₇H₃₆N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	135062-02-1
PubChem ID	65981
InChi Key	FAEKWTJYAYMJKF-QHCPKHFHSA-N
Smiles	O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Repaglinide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.26	100
	ethanol	45.26	100

Preparing Stock Solutions for Repaglinide

The following data is based on the product molecular weight 452.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Repaglinide

References are publications that support the biological activity of the product.

Hansen Kir6.2-dependent high-affinity repagl. binding to β-cell K_ATP channels. Br.J.Pharmacol. 2005 PMID: 15678092
Mark and Grell Hypoglycaemic effects of the novel antidiabetic agent repagl. in rats and dogs. Br.J.Pharmacol. 1997 PMID: 9283692