Reboxetine mesylate

Name: Reboxetine mesylate
Brand: Tocris Bioscience
SKU: 1982
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1982

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Citations (51)

COA / SDS

Potent and selective noradrenalin uptake inhibitor; orally active

Key Product Details

Description:	Potent and selective noradrenalin uptake inhibitor; orally active
Chemical Name:	(2R)-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	409.5

View Full Technical Details for Reboxetine mesylate

Technical Data
Citations / Reviews (1)

Biological Activity for Reboxetine mesylate

Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (K_i values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Compound Libraries for Reboxetine mesylate

Reboxetine mesylate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Reboxetine mesylate

M. Wt	409.5
Formula	C₁₉H₂₃NO₃.CH₃SO₃H
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	98769-84-7
PubChem ID	76970698
InChi Key	OEQQXKDUXVTKMH-BGLVZNNJSA-N
Smiles	[H][C@]2(OCCNC2)[C@@H]([C@]3=CC=CC=C3)OC1=C(OCC)C=CC=C1.[H][C@@]5(OCCNC5)[C@H]([C@]6=CC=CC=C6)OC4=C(OCC)C=CC=C4.CS(=O)(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Reboxetine mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.48	50
	DMSO	20.48	50

Preparing Stock Solutions for Reboxetine mesylate

The following data is based on the product molecular weight 409.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.88 mL	24.42 mL	48.84 mL
2.5 mM	0.98 mL	4.88 mL	9.77 mL
5 mM	0.49 mL	2.44 mL	4.88 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

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References for Reboxetine mesylate

References are publications that support the biological activity of the product.

Owen and Whitton Reboxetine modulates NE efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT_1A receptors. Neurosci.Lett. 2003 PMID: 12932821
Wong Reboxetine: a pharmacologically potent, selective, and specific NE reuptake inhibitor. Biol.Psychiatry. 2000 PMID: 10812041
Millan S33005, a novel ligand at both serotonin and NE transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. J.Pharmacol.Exp.Ther. 2001 PMID: 11454918
Sacchetti Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. Br.J.Pharmacol. 1999 PMID: 10578149