Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I_Na and I_Kr currents.

Product Specifications

Molecular Weight

500.46

Formula

C₂₄H₃₃N₃O₄.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

CAS Number

95635-56-6

PubChem ID

71279

InChI Key

RJNSNFZXAZXOFX-UHFFFAOYSA-N

SMILES

COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.05	100
	DMSO	50.05	100

Preparing Stock Solutions for Ranolazine dihydrochloride

The following data is based on the product molecular weight 500.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Shryock and Belardinelli Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br.J.Pharmacol. 2008 PMID: 18071302
Wang Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J.Pharmacol.Exp.Ther. 2008 PMID: 18322148
Zacharowski Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur.J.Pharmacol. 2001 PMID: 11334871

Ranolazine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3118

Key Product Details

Description

Alternative Names

View all Dehydrogenase Activators »

Product Description