R18
Tocris Bioscience, part of Bio-Techne | Catalog # 2144
Inhibitor of 14.3.3 proteins
Product Description
R18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.Product Specifications
Molecular Weight
2309.69
Formula
C101H157N27O29S3
Storage
Store at -20°C
Purity
≥90% (HPLC)
CAS Number
211364-78-2
PubChem ID
16138697
InChI Key
YSKZRNFKZLWXRG-ZHTKBQOPSA-N
SMILES
[H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Masters and Fu 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 2001 PMID: 11577088
- Masters Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions
- Wang Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 1999 PMID: 10493820
Product Specific Notices for R18
For research use only
Loading...
Loading...