(R)-ZINC 3573

Name: ( R )-ZINC 3573
Brand: Tocris Bioscience
SKU: 6351

Tocris Bioscience, part of Bio-Techne | Catalog # 6351

COA / SDS

MRGPRX2 agonist

Key Product Details

Description:	MRGPRX2 agonist
Chemical Name:	(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	307.4

View Full Technical Details for (R)-ZINC 3573

Technical Data
Citations

Biological Activity for (R)-ZINC 3573

(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC₅₀ = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

Compound Libraries for (R)-ZINC 3573

(R)-ZINC 3573 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.

Technical Data for (R)-ZINC 3573

M. Wt	307.4
Formula	C₁₈H₂₁N₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2089389-15-9
PubChem ID	95882507
InChi Key	XKBSPAZCFAIBJL-OAHLLOKOSA-N
Smiles	CN([C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-ZINC 3573

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	30.74	100
	DMSO	30.74	100

Preparing Stock Solutions for (R)-ZINC 3573

The following data is based on the product molecular weight 307.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.53 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for (R)-ZINC 3573

References are publications that support the biological activity of the product.

Lansu In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 2017 PMID: 28288109