(R,R)-THC

Name: ( R , R )-THC
Brand: Tocris Bioscience
SKU: 1990

Tocris Bioscience, part of Bio-Techne | Catalog # 1990

Citations (82)

COA / SDS

Potent subtype-selective ligand; ERα agonist/ERβ antagonist

Key Product Details

Description:	Potent subtype-selective ligand; ERα agonist/ERβ antagonist
Chemical Name:	(R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Purity:	≥98% (HPLC)
Molecular Weight:	320.42

View Full Technical Details for (R,R)-THC

Technical Data
Citations

Biological Activity for (R,R)-THC

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (K_i = 9.0 nM) and antagonist at ERβ receptor (K_i = 3.6 nM).

Technical Data for (R,R)-THC

M. Wt	320.42
Formula	C₂₂H₂₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	138090-06-9
PubChem ID	446849
InChi Key	MASYAWHPJCQLSW-ZIAGYGMSSA-N
Smiles	OC3=CC=C(C(C[C@H]4CC)=C3)C2=C4C1=CC=C(O)C=C1C[C@H]2CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R,R)-THC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.04	100
	ethanol	32.04	100

Preparing Stock Solutions for (R,R)-THC

The following data is based on the product molecular weight 320.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.60 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for (R,R)-THC

References are publications that support the biological activity of the product.

Kraichely Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 2000 PMID: 11014206
Meyers Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J.Med.Chem. 1999 PMID: 10395487
Sun Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β. Endocrinology 1999 PMID: 9927308