(R)-(+)-HA-966
Tocris Bioscience, part of Bio-Techne | Catalog # 0281
NMDA partial agonist/antagonist; acts at glycine site
Key Product Details
Description
NMDA partial agonist/antagonist; acts at glycine site
Product Description
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
116.12
Formula
C4H8N2O2
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
CAS Number
123931-04-4
PubChem ID
6603720
InChI Key
HCKUBNLZMKAEIN-GSVOUGTGSA-N
SMILES
N[C@@H]1CCN(O)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.61 | 100 |
Preparing Stock Solutions
for (R)-(+)-HA-966
The following data is based on the product molecular weight 116.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.61 mL | 43.06 mL | 86.12 mL |
| 5 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 10 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 50 mM | 0.17 mL | 0.86 mL | 1.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pullan Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 1990 PMID: 1975835
- Pullan Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 1991 PMID: 1834473
- Kemp and Priestley Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 1991 PMID: 1674587
Product Specific Notices for (R)-(+)-HA-966
For research use only
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