(R)-(+)-Etomoxir sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 4539
Carnitine palmitoyltransferase I (CPT1) inhibitor
Key Product Details
Description
Carnitine palmitoyltransferase I (CPT1) inhibitor
Product Description
(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.Product Specifications
Molecular Weight
320.74
Formula
C15H18ClNaO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
CAS Number
828934-41-4
PubChem ID
57345784
InChI Key
RPACBEVZENYWOL-XFULWGLBSA-M
SMILES
[Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.41 | 20 | |
| DMSO | 6.41 | 20 with gentle warming |
Preparing Stock Solutions
for (R)-(+)-Etomoxir sodium salt
The following data is based on the product molecular weight 320.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.59 mL | 77.94 mL | 155.89 mL |
| 1 mM | 3.12 mL | 15.59 mL | 31.18 mL |
| 2 mM | 1.56 mL | 7.79 mL | 15.59 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Agius Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 1991 PMID: 1930298
- Rupp Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 1992 PMID: 1531968
- Xu Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 2003 PMID: 12576524
Product Specific Notices for (R)-(+)-Etomoxir sodium salt
For research use only
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