(R)-MG 132
Tocris Bioscience, part of Bio-Techne | Catalog # 6033
Potent 20S proteasome inhibitor
Product Description
(R)-MG 132 is a potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.Product Specifications
Molecular Weight
475.63
Formula
C26H41N3O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
CAS Number
1211877-36-9
PubChem ID
45103781
InChI Key
TZYWCYJVHRLUCT-ZRBLBEILSA-N
SMILES
CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.56 | 100 | |
| Ethanol | 9.51 | 20 |
Preparing Stock Solutions
for (R)-MG 132
The following data is based on the product molecular weight 475.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.10 mL | 10.51 mL | 21.02 mL |
| 5 mM | 0.42 mL | 2.10 mL | 4.20 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.10 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mroczkiewicz Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 2010 PMID: 20112914
Product Specific Notices for (R)-MG 132
For research use only
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