R 7050

Tocris Bioscience, part of Bio-Techne | Catalog # 5432

Inhibitor of TNF-α receptor 1 signaling
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Key Product Details

Description

Inhibitor of TNF-α receptor 1 signaling

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Product Description

R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Product Specifications

Molecular Weight

380.77

Formula

C16H8ClF3N4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

CAS Number

303997-35-5

PubChem ID

1486608

InChI Key

SUUMKHOVGVYGOP-UHFFFAOYSA-N

SMILES

ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.62 20

Preparing Stock Solutions for R 7050

The following data is based on the product molecular weight 380.77

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.13 mL 65.66 mL 131.31 mL
1 mM 2.63 mL 13.13 mL 26.26 mL
2 mM 1.31 mL 6.57 mL 13.13 mL
10 mM 0.26 mL 1.31 mL 2.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for R 7050

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for R 7050

For research use only

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