R 1530

Name: R 1530
Brand: Tocris Bioscience
SKU: 4885

Tocris Bioscience, part of Bio-Techne | Catalog # 4885

COA / SDS

Multi-RTK inhibitor; inhibits angiogenesis

Discontinued Product

4885 has been discontinued. View all Additional RTK Inhibitors products.

Key Product Details

Description:	Multi-RTK inhibitor; inhibits angiogenesis
Chemical Name:	5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo[3,4-b][1,4]benzodiazepine
Purity:	≥98% (HPLC)
Molecular Weight:	356.78

View Full Technical Details for R 1530

Technical Data
Citations

Biological Activity for R 1530

R 1530 is a multi-kinase inhibitor. Exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2 (IC₅₀ values are 24, 34, 50, 58 and 88 nM respectively). Also binds VEGFR-2, FGFR1 and PDGFRβ (K_d values are 0.015, 0.061 and 0.088 μM respectively). Displays antiproliferative activity in vitro; inhibits mitosis and angiogenesis. Orally bioavailable.

Technical Data for R 1530

M. Wt	356.78
Formula	C₁₈H₁₄ClFN₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	882531-87-5
PubChem ID	11610113
InChi Key	UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Smiles	FC(C(OC)=C1)=CC2=C1NC3=NNC(C)=C3N=C2C4=C(Cl)C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for R 1530

References are publications that support the biological activity of the product.

Tovar Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: implications for therapy. Cell Cycle 2010 PMID: 20814247
Liu Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor R1530 for the treatment of solid tumors. ACS Med.Chem.Lett.

R 1530

Tocris Bioscience, part of Bio-Techne | Catalog # 4885

Key Product Details

Biological Activity for R 1530

Technical Data for R 1530

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for R 1530

Product Documents for R 1530

COA

Certificate of Analysis

SDS

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