R 1530

Tocris Bioscience, part of Bio-Techne | Catalog # 4885

Multi-RTK inhibitor; inhibits angiogenesis
Discontinued Product
4885 has been discontinued. View all Additional RTK Inhibitors products.

Key Product Details

Description

Multi-RTK inhibitor; inhibits angiogenesis

View all Additional RTK Inhibitors »

Product Description

R 1530 is a multi-kinase inhibitor. Exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2 (IC50 values are 24, 34, 50, 58 and 88 nM respectively). Also binds VEGFR-2, FGFR1 and PDGFRβ (Kd values are 0.015, 0.061 and 0.088 μM respectively). Displays antiproliferative activity in vitro; inhibits mitosis and angiogenesis. Orally bioavailable.

Product Specifications

Molecular Weight

356.78

Formula

C18H14ClFN4O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo[3,4-b][1,4]benzodiazepine

CAS Number

882531-87-5

PubChem ID

11610113

InChI Key

UOVCGJXDGOGOCZ-UHFFFAOYSA-N

SMILES

FC(C(OC)=C1)=CC2=C1NC3=NNC(C)=C3N=C2C4=C(Cl)C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.68 100
Ethanol 35.68 100

Preparing Stock Solutions for R 1530

The following data is based on the product molecular weight 356.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.80 mL 14.01 mL 28.03 mL
5 mM 0.56 mL 2.80 mL 5.61 mL
10 mM 0.28 mL 1.40 mL 2.80 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for R 1530

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for R 1530

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.