QWF

Name: QWF
Brand: Tocris Bioscience
SKU: 6642

Tocris Bioscience, part of Bio-Techne | Catalog # 6642

Citations (13)

COA / SDS

MRGPRX2 antagonist; also NK1 receptor antagonist

Key Product Details

Description:	MRGPRX2 antagonist; also NK₁ receptor antagonist
Purity:	≥90% (HPLC)
Molecular Weight:	697.78

View Full Technical Details for QWF

Technical Data
Citations

Biological Activity for QWF

QWF is a tripeptide substance P (SP) antagonist (IC₅₀ = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. QWF can be used in a small molecule cocktail to generate 3D culture of lung alveolar cells (see protocol below).

For more information about how QWF may be used, see our protocol: 3D Culture of Lung Alveolar Cells

Technical Data for QWF

M. Wt	697.78
Formula	C₃₈H₄₃N₅O₈
Single Letter Sequence	QWF (Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl)
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	126088-82-2
PubChem ID	336446954
InChi Key	ZFZOHFAASQHWER-NCRUWMDKNA-N
Smiles	CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QWF

Solubility

Soluble to 10mg/ml in DMSO

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References for QWF

References are publications that support the biological activity of the product.

Azimi Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 2016 PMID: 27734033
Hagiwara Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 1992 PMID: 1375965

QWF

Tocris Bioscience, part of Bio-Techne | Catalog # 6642

Key Product Details

Biological Activity for QWF

Technical Data for QWF

Solubility for QWF

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for QWF

Product Documents for QWF

COA

Certificate of Analysis

SDS

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