Quinidine
Tocris Bioscience, part of Bio-Techne | Catalog # 4108
Blocks sodium and potassium channels
Key Product Details
Description
Blocks sodium and potassium channels
Product Description
Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).Product Specifications
Molecular Weight
324.42
Formula
C20H24N2O2
Storage
Store at -20°C
Chemical Name
(S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
CAS Number
56-54-2
PubChem ID
3036746
InChI Key
LOUPRKONTZGTKE-LHFMAAMQSA-N
SMILES
O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 | |
| Ethanol | 8.11 | 25 |
Preparing Stock Solutions
for Quinidine
The following data is based on the product molecular weight 324.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.82 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.16 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Borggrefe Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 2005 PMID: 16226079
- Wu Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 2008 PMID: 19084812
- Caballero Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 2003 PMID: 12721103
Product Specific Notices for Quinidine
For research use only
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