QNZ 46
Tocris Bioscience, part of Bio-Techne | Catalog # 4801
Non-competitive and GluN2C/GluN2D-selective NMDA antagonist
Key Product Details
Description
Non-competitive and GluN2C/GluN2D-selective NMDA antagonist
Product Description
QNZ 46 is a GluN2C/GluN2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for GluN2D, GluN2C, GluN2A, GluN2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
443.41
Formula
C24H17N3O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
CAS Number
1237744-13-6
PubChem ID
46861929
InChI Key
GNLVJIICVWDSNI-LFYBBSHMSA-N
SMILES
O=C2C1=CC(OC)=CC=C1N=C(/C=C/C4=CC([N+]([O-])=O)=CC=C4)N2C3=CC=C(C(O)=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.43 | 10 with gentle warming |
Preparing Stock Solutions
for QNZ 46
The following data is based on the product molecular weight 443.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.76 mL | 225.52 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.10 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hansen and Traynelis Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 2011 PMID: 21389220
- Mosley Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-MthD.-aspartate receptor antagonists. J.Med.Chem. 2010 PMID: 20684595
Product Specific Notices for QNZ 46
For research use only
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