QAQ dichloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5470
Photoswitchable Nav, Kv and Cav channel blocker
Discontinued Product
5470 has been discontinued.
View all Non-selective Cav Blockers products.
Key Product Details
Description
Photoswitchable Nav, Kv and Cav channel blocker
Product Description
QAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.Product Specifications
Molecular Weight
567.59
Formula
C28H44Cl2N6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
PubChem ID
91826091
InChI Key
VHURBRSYOFCHNY-UHFFFAOYSA-N
SMILES
O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.38 | 50 |
Preparing Stock Solutions
for QAQ dichloride
The following data is based on the product molecular weight 567.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.52 mL | 17.62 mL | 35.24 mL |
| 2.5 mM | 0.70 mL | 3.52 mL | 7.05 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Banghart MR Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID: 19882609
- Mourot Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 2012 PMID: 22343342
Product Specific Notices for QAQ dichloride
For research use only
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