PSEM 308 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6425
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Key Product Details
Description
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Product Description
PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.Recommended concentration for use in mice is 5 mg/kg or lower.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Product Specifications
Molecular Weight
303.83
Formula
C17H21N3.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyridodiazepino[6,7,1-hi]indole hydrochloride
PubChem ID
134812838
InChI Key
VMTPPUMVLGEJNP-UHFFFAOYSA-N
SMILES
CC1CC2=CC=CC3=C2N1N=C4C(C3)[N@@]5CC[C@H]4CC5.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.08 | 20 | |
| Ethanol | 6.08 | 20 with gentle warming |
Preparing Stock Solutions
for PSEM 308 hydrochloride
The following data is based on the product molecular weight 303.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.46 mL | 82.28 mL | 164.57 mL |
| 1 mM | 3.29 mL | 16.46 mL | 32.91 mL |
| 2 mM | 1.65 mL | 8.23 mL | 16.46 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hirschberg Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 2017 PMID: 29027903
- Satoh Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 2016 PMID: 26924434
- Atasoy Deconstruction of a neural circuit for hunger. Nature 2012 PMID: 22801496
- Lovett-Barron Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 2012 PMID: 22246433
Product Specific Notices for PSEM 308 hydrochloride
For research use only
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