PSB 12379
Tocris Bioscience, part of Bio-Techne | Catalog # 6083
Ecto-5'-nucleotidase (CD73) inhibitor
Key Product Details
Description
Ecto-5'-nucleotidase (CD73) inhibitor
Product Description
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.Product Specifications
Molecular Weight
559.31
Formula
C18H21N5Na2O9P2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
PubChem ID
131648246
InChI Key
CGXINRNHTNDEBI-BUPZQQHBSA-L
SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578
- Bhattarai α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 2015 PMID: 26147331
Product Specific Notices for PSB 12379
For research use only
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