PSB 1115
Tocris Bioscience, part of Bio-Techne | Catalog # 2009
Selective human A2B antagonist; water-soluble
Key Product Details
Description
Selective human A2B antagonist; water-soluble
Product Description
PSB 1115 is a highly selective, water-soluble, human A2B adenosine receptor antagonist. Ki values are 53.4, > 10000 and > 10000 nM at human A2B, A1 and A3 receptors respectively. Also selective versus rat A1 and A2A receptors (Ki values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.Product Specifications
Molecular Weight
350.35
Formula
C14H14N4O5S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid
CAS Number
152529-79-8
PubChem ID
5311479
InChI Key
UYDRRQPGDSIMNU-UHFFFAOYSA-N
SMILES
O=C(NC2=C1NC(C3=CC=C(S(=O)(O)=O)C=C3)=N2)N(CCC)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.77 | 20 with gentle warming | |
| DMSO | 38.84 | 100 |
Preparing Stock Solutions
for PSB 1115
The following data is based on the product molecular weight 350.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yan and Muller Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 2004 PMID: 14761205
- Hayallah 1,8-Disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. J.Med.Chem. 2002 PMID: 11906291
- Abo-Salem Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 2004 PMID: 14563788
- Muller 8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 1998 PMID: 9681137
Product Specific Notices for PSB 1115
For research use only
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