ProTx II

Name: ProTx II
Brand: Tocris Bioscience
SKU: 4023

Tocris Bioscience, part of Bio-Techne | Catalog # 4023

Citations (20)

COA / SDS

Selective NaV1.7 channel blocker

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective NaV1.7 channel blocker

View all Voltage-gated Sodium Channel Blockers »

Product Description

ProTx II is a selective Na_V1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.

Product Specifications

Molecular Weight

3826.59

Formula

C₁₆₈H₂₅₀N₄₆O₄₁S₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

484598-36-9

PubChem ID

118708662

InChI Key

XOAUGYVLRSCGBG-ZJDFQAAZSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Xu Structural basis of Na_v1.7 inhibition by a gating-modifier spider toxin. Cell. 2019 PMID: 30661758
Edgerton Evidence for multiple effects of ProTxII on activation gating in Na_V 1.5. Toxicon. 2008 PMID: 18657562
Schmalhofer ProTx-II, a selective inhibitor of Na_V 1.7 sodium channels, blocks action potential propagation in nociceptors. Mol.Pharmacol. 2008 PMID: 18728100
Smith Molecular interactions of the gating modifier toxin ProTx-II with Na_V 1.5: implied existence of a novel toxin binding site coupled to activation. J.Biol.Chem. 2007 PMID: 17339321