ProINDY
Tocris Bioscience, part of Bio-Techne | Catalog # 4998
DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)
Discontinued Product
4998 has been discontinued.
View all DYRK Inhibitors products.
Key Product Details
Description
DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)
Product Description
ProINDY is a DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.Product Specifications
Molecular Weight
277.34
Formula
C14H15NO3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
CAS Number
719277-30-2
PubChem ID
68879595
InChI Key
RLEOCVDWLAYGRX-UHFFFAOYSA-N
SMILES
O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.73 | 100 |
Preparing Stock Solutions
for ProINDY
The following data is based on the product molecular weight 277.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.21 mL |
| 10 mM | 0.36 mL | 1.80 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ogawa Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 2010 PMID: 20981014
Product Specific Notices for ProINDY
For research use only
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