Probenecid

Name: Probenecid
Brand: Tocris Bioscience
SKU: 4107

Tocris Bioscience, part of Bio-Techne | Catalog # 4107

Citations (44)

COA / SDS

MRP and OAT3 inhibitor

Key Product Details

Description:	MRP and OAT3 inhibitor
Chemical Name:	4-(Dipropylsulfamoyl)benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	285.36

View Full Technical Details for Probenecid

Technical Data
Citations

Biological Activity for Probenecid

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC₅₀ ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC₅₀= 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

Compound Libraries for Probenecid

Probenecid is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Probenecid

M. Wt	285.36
Formula	C₁₃H₁₉NO₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	57-66-9
PubChem ID	4911
InChi Key	DBABZHXKTCFAPX-UHFFFAOYSA-N
Smiles	O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Probenecid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.54	100
	ethanol	28.54	100

Preparing Stock Solutions for Probenecid

The following data is based on the product molecular weight 285.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.52 mL	35.04 mL
5 mM	0.70 mL	3.50 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Probenecid

References are publications that support the biological activity of the product.

Murray Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci.Rep. 2021 PMID: 34508172
Perwitasai Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 2013 PMID: 23129053
Ishikawa Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 2010 PMID: 20190417
Silverman Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 2008 PMID: 18596212
Hammond Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 2007 PMID: 17374608
Cunningham Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 1981 PMID: 7011657