Pregnenolone sulfate sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5376
NMDA potentiator; also GABAA inhibitor and TRPM3 activator
Key Product Details
Description
NMDA potentiator; also GABAA inhibitor and TRPM3 activator
Product Description
Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.Product Specifications
Molecular Weight
418.52
Formula
C21H31NaO5S
Storage
Store at +4°C
Chemical Name
(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
CAS Number
1852-38-6
PubChem ID
23676306
InChI Key
QQVJEIZJHDPTSH-UTNKIXDHSA-M
SMILES
O=[C@](C)[C@H]4CC[C@@]3([H])[C@]2([H])CC=C1C[C@@H](OS(=O)([O-])=O)CC[C@@](C)1[C@]([H])2CC[C@@]34C.[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.93 | 50 |
Preparing Stock Solutions
for Pregnenolone sulfate sodium salt
The following data is based on the product molecular weight 418.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.78 mL | 23.89 mL | 47.79 mL |
| 2.5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 25 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seljeset Probing GABAA receptors with inhibitory neurosteroids. Neuropharmacology 2018 PMID: 29447845
- Majeed Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 2010 PMID: 20735426
- Smith A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 2014 PMID: 25057049
- Li Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 2007 PMID: 17636008
Product Specific Notices for Pregnenolone sulfate sodium salt
For research use only
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