Pregnenolone sulfate sodium salt

Name: Pregnenolone sulfate sodium salt
Brand: Tocris Bioscience
SKU: 5376

Tocris Bioscience, part of Bio-Techne | Catalog # 5376

Citations (7)

COA / SDS

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

Key Product Details

Description:	NMDA potentiator; also GABA_A inhibitor and TRPM3 activator
Chemical Name:	(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
Molecular Weight:	418.52

View Full Technical Details for Pregnenolone sulfate sodium salt

Technical Data
Citations

Biological Activity for Pregnenolone sulfate sodium salt

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca²⁺ upon NMDA receptor-mediated synaptic activity (EC₅₀ ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABA_A receptors (IC₅₀ values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Technical Data for Pregnenolone sulfate sodium salt

M. Wt	418.52
Formula	C₂₁H₃₁NaO₅S
Storage	Store at +4°C
CAS Number	1852-38-6
PubChem ID	23676306
InChi Key	QQVJEIZJHDPTSH-UTNKIXDHSA-M
Smiles	O=[C@](C)[C@H]4CC[C@@]3([H])[C@]2([H])CC=C1C[C@@H](OS(=O)([O-])=O)CC[C@@](C)1[C@]([H])2CC[C@@]34C.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pregnenolone sulfate sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.93	50

Preparing Stock Solutions for Pregnenolone sulfate sodium salt

The following data is based on the product molecular weight 418.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.78 mL	23.89 mL	47.79 mL
2.5 mM	0.96 mL	4.78 mL	9.56 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

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References for Pregnenolone sulfate sodium salt

References are publications that support the biological activity of the product.

Seljeset Probing GABA_A receptors with inhibitory neurosteroids. Neuropharmacology 2018 PMID: 29447845
Majeed Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 2010 PMID: 20735426
Smith A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2⁺ signaling and CREB activation. Mol.Pharmacol. 2014 PMID: 25057049
Li Neuroactive steroids and human recombinant rho1 GABA_C receptors. J.Pharmacol.Exp.Ther. 2007 PMID: 17636008