Pravastatin sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 2318
HMG-CoA reductase inhibitor
Key Product Details
Description
HMG-CoA reductase inhibitor
Alternative Names
Eptastatin sodium
Product Description
Pravastatin sodium salt is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.Product Specifications
Molecular Weight
446.51
Formula
C23H35NaO7
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
CAS Number
81131-70-6
PubChem ID
16759173
InChI Key
VWBQYTRBTXKKOG-IYNICTALSA-M
SMILES
[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.65 | 100 | |
| DMSO | 44.65 | 100 |
Preparing Stock Solutions
for Pravastatin sodium salt
The following data is based on the product molecular weight 446.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.20 mL | 22.40 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hamelin and Turgeon Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 1998 PMID: 9509899
Product Specific Notices for Pravastatin sodium salt
For research use only
⚠ WARNING: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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