Pramipexole dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4174
Selective D3 agonist
Product Description
Pramipexole dihydrochloride is a dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.Product Specifications
Molecular Weight
284.25
Formula
C10H17N3S.2HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
CAS Number
104632-25-9
PubChem ID
119569
InChI Key
QMNWXHSYPXQFSK-KLXURFKVSA-N
SMILES
NC(S2)=NC1=C2C[C@@H](NCCC)CC1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.43 | 100 | |
| DMSO | 28.43 | 100 |
Preparing Stock Solutions
for Pramipexole dihydrochloride
The following data is based on the product molecular weight 284.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.18 mL |
| 5 mM | 0.70 mL | 3.52 mL | 7.04 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mierau Pramipexole binding and activation of cloned and expressed DA D2, D3 and D4 receptors. Eur.J.Pharmacol. 1995 PMID: 7664822
Product Specific Notices for Pramipexole dihydrochloride
For research use only
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