PPQ 102

Name: PPQ 102
Brand: Tocris Bioscience
SKU: 4303
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4303

(1)

Citations (9)

COA / SDS

Potent, voltage-independent CFTR chloride channel inhibitor

Discontinued Product

4303 has been discontinued. View all CFTR Blockers products.

Key Product Details

Description:	Potent, voltage-independent CFTR chloride channel inhibitor
Chemical Name:	6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	438.48

View Full Technical Details for PPQ 102

Technical Data
Citations / Reviews (1)

Biological Activity for PPQ 102

PPQ 102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC₅₀ = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.

Technical Data for PPQ 102

M. Wt	438.48
Formula	C₂₆H₂₂N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	931706-15-9
PubChem ID	16016583
InChi Key	MNOOVRNGPIWJDI-UHFFFAOYSA-N
Smiles	O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PPQ 102

References are publications that support the biological activity of the product.

Martin CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 2013 PMID: 23520314
Tradtrantip Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 2009 PMID: 19785436

PPQ 102

Tocris Bioscience, part of Bio-Techne | Catalog # 4303

Key Product Details

Biological Activity for PPQ 102

Technical Data for PPQ 102

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PPQ 102

Product Documents for PPQ 102

COA

Certificate of Analysis

SDS

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