PPDA
Tocris Bioscience, part of Bio-Techne | Catalog # 2530
GluN2C/GluN2D-selective NMDA antagonist
Key Product Details
Description
GluN2C/GluN2D-selective NMDA antagonist
Product Description
PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Licensing Information
Sold under license from UNeMed Corporation.Product Specifications
Molecular Weight
378.38
Formula
C21H18N2O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
CAS Number
684283-16-7
PubChem ID
90488770
InChI Key
FAQARVDXAFZICA-QVUSPSOHSA-N
SMILES
O=C(C2=CC=C3C(C=CC4=C3C=CC=C4)=C2)N1[C@@H]([C@](O)=O)[C@@H]([C@](O)=O)NCC1.O=C(C6=CC=C7C(C=CC8=C7C=CC=C8)=C6)N5[C@H](C(O)=O)[C@H](C(O)=O)NCC5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq. NaOH | 18.92 | 50 | |
| DMSO | 37.84 | 100 |
Preparing Stock Solutions
for PPDA
The following data is based on the product molecular weight 378.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.21 mL | 26.43 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.29 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Morley Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 2005 PMID: 15801853
- Kinarsky Identification of subunit- and antagonist-specific amino acid residues in the N-MthD.-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 2005 PMID: 15743930
- Feng Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 2004 PMID: 14718249
Product Specific Notices for PPDA
For research use only
Loading...
Loading...