PPDA

Name: PPDA
Brand: Tocris Bioscience
SKU: 2530

Tocris Bioscience, part of Bio-Techne | Catalog # 2530

Citations (43)

COA / SDS

GluN2C/GluN2D-selective NMDA antagonist

Key Product Details

Description:	GluN2C/GluN2D-selective NMDA antagonist
Chemical Name:	(2S,3R)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	378.38

View Full Technical Details for PPDA

Technical Data
Citations

Biological Activity for PPDA

PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (K_i values are 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Licensing Information

Sold under license from UNeMed Corporation.

Compound Libraries for PPDA

PPDA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PPDA

M. Wt	378.38
Formula	C₂₁H₁₈N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	684283-16-7
PubChem ID	90488770
InChi Key	FAQARVDXAFZICA-QVUSPSOHSA-N
Smiles	O=C(C2=CC=C3C(C=CC4=C3C=CC=C4)=C2)N1[C@@H]([C@](O)=O)[C@@H]([C@](O)=O)NCC1.O=C(C6=CC=C7C(C=CC8=C7C=CC=C8)=C6)N5[C@H](C(O)=O)[C@H](C(O)=O)NCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PPDA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	2eq. NaOH	18.92	50
	DMSO	37.84	100

Preparing Stock Solutions for PPDA

The following data is based on the product molecular weight 378.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for PPDA

References are publications that support the biological activity of the product.

Morley Synthesis and pharmacology of N₁-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 2005 PMID: 15801853
Kinarsky Identification of subunit- and antagonist-specific amino acid residues in the N-MthD.-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 2005 PMID: 15743930
Feng Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 2004 PMID: 14718249