PP 1
Tocris Bioscience, part of Bio-Techne | Catalog # 1397
Potent, selective Src family kinase inhibitor
Key Product Details
Description
Potent, selective Src family kinase inhibitor
Product Description
PP 1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.Product Specifications
Molecular Weight
281.36
Formula
C16H19N5
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
172889-26-8
PubChem ID
1400
InChI Key
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
SMILES
CC1=CC=C(C=C1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10 | ||
| Ethanol | 10 |
Preparing Stock Solutions
for PP 1
The following data is based on the product molecular weight 281.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.54 mL | 177.71 mL | 355.42 mL |
| 0.5 mM | 7.11 mL | 35.54 mL | 71.08 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.54 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tatton The src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J.Biol.Chem. 2003 PMID: 12475982
- Liu Structural basis for selective inhibition of Src family kinases by PP1. Chem.Biol. 1999 PMID: 10467133
- Carlomagno The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res. 2002 PMID: 11861385
- Hanke Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor. J.Biol.Chem. 1996 PMID: 8557675
- Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346
Product Specific Notices for PP 1
For research use only
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