PNU 74654

Name: PNU 74654
Brand: Tocris Bioscience
SKU: 3534
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3534

(1)

Citations (34)

COA / SDS

β-catenin binder; inhibits Wnt signaling

Key Product Details

Description:	β-catenin binder; inhibits Wnt signaling
Chemical Name:	2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	320.34

View Full Technical Details for PNU 74654

Technical Data
Citations / Reviews (1)

Biological Activity for PNU 74654

Binds to β-catenin (K_D = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.

Compound Libraries for PNU 74654

PNU 74654 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for PNU 74654

M. Wt	320.34
Formula	C₁₉H₁₆N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	113906-27-7
PubChem ID	9836739
InChi Key	JJEDWBQZCRESJL-DEDYPNTBSA-N
Smiles	O=C(N/N=C/C2=CC=C(C)O2)C1=C(OC3=CC=CC=C3)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PNU 74654

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.03	100

Preparing Stock Solutions for PNU 74654

The following data is based on the product molecular weight 320.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.61 mL	31.22 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for PNU 74654

References are publications that support the biological activity of the product.

Wells and McClendon Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007 PMID: 18075579
Chen Chemically defined neural conversion of human pluripotent stem cells. Methods Mol.Biol. 2019 PMID: 30656621
Trosset Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 2006 PMID: 16568448