PNU 282987
Tocris Bioscience, part of Bio-Techne | Catalog # 2303
Selective α7 nAChR agonist
Key Product Details
Description
Selective α7 nAChR agonist
Product Description
PNU 282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).Product Specifications
Molecular Weight
264.75
Formula
C14H17ClN2O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
CAS Number
711085-63-1
PubChem ID
9795278
InChI Key
WECKJONDRAUFDD-ZDUSSCGKSA-N
SMILES
O=C(C2=CC=C(Cl)C=C2)N[C@@H]1C3CCN(CC3)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 26.48 | 100 | |
| DMSO | 26.48 | 100 |
Preparing Stock Solutions
for PNU 282987
The following data is based on the product molecular weight 264.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.89 mL | 37.77 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.55 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hajós The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe J.Pharmacol.Exp.Ther. 2005 PMID: 15523001
- Bodnar Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J.Med.Chem. 2005 PMID: 15715459
Product Specific Notices for PNU 282987
For research use only
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