PNU 120596

Tocris Bioscience, part of Bio-Techne | Catalog # 2498

Positive allosteric modulator of α7 nAChRs; active in vivo
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Key Product Details

Description

Positive allosteric modulator of α7 nAChRs; active in vivo

View all Nicotinic (a7) Receptor Modulators »

Product Description

PNU 120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.

Product Specifications

Molecular Weight

311.72

Formula

C13H14ClN3O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea

CAS Number

501925-31-1

PubChem ID

311434

InChI Key

CEIIEALEIHQDBX-UHFFFAOYSA-N

SMILES

COC1=CC(OC)=C(Cl)C=C1NC(=O)NC1=NOC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.17 100

Preparing Stock Solutions for PNU 120596

The following data is based on the product molecular weight 311.72

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.04 mL 32.08 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.60 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PNU 120596

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PNU 120596

For research use only

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