PMX 53

Tocris Bioscience, part of Bio-Techne | Catalog # 5473

(1)

Citations (27)

COA / SDS

Potent C5a receptor antagonist

Key Product Details

Description:	Potent C5a receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	896.1

View Full Technical Details for PMX 53

Technical Data
Citations / Reviews (1)

Biological Activity for PMX 53

PMX 53 is a potent C5a receptor antagonist (IC₅₀ = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.

Negative Control also available.

Technical Data for PMX 53

M. Wt	896.1
Formula	C₄₇H₆₅N₁₁O₇
Single Letter Sequence	FXPXWR (Modifications: Phe-1 = N-terminal Ac, X-2 = Orn, X-4 = D-Cha, Lactam bridge: Orn-2 to Arg-6)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	219639-75-5
PubChem ID	23526550
InChi Key	YOKBGCTZYPOSQM-UHFFFAOYSA-N
Smiles	NC(=NCCCC1NC(=O)C(NC(=O)C(CC2CCCCC2)NC(=O)C2N(C(=O)C(CCCNC1=O)NC(=O)C(Cc1ccccc1)NC(=O)C)CCC2)Cc1c[nH]c2c1cccc2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PMX 53

Solubility

Soluble to 2mg/ml in water

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References for PMX 53

References are publications that support the biological activity of the product.

Kumar Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci.Rep. 2018 PMID: 29802264
Manthey Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J 2011 PMID: 21490292
Vadrevu Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche. Cancer Res. 2014 PMID: 24786787
Finch Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J.Med.Chem. 1999 PMID: 10354404
Subramanian PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Mol.Pharmacol. 2011 PMID: 21441599
Ting Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain. Br.J.Pharmacol. 2008 PMID: 18084313