PMX 205

Tocris Bioscience, part of Bio-Techne | Catalog # 5196

Citations (25)

COA / SDS

Potent C5a receptor peptide antagonist

100% Guarantee

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent C5a receptor peptide antagonist

View all Complement Signaling Compounds »

Product Description

PMX 205 is a potent C5a receptor peptide antagonist (IC₅₀ = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Product Specifications

Molecular Weight

839.05

Formula

C₄₅H₆₂N₁₀O₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

514814-49-4

PubChem ID

90489023

InChI Key

YUIBSMOWXFHTBD-UHFFFAOYSA-N

SMILES

NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water with sonication

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Kumar Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci.Rep. 2018 PMID: 29802264
Lee Pharmacological inhibition of complement C5a-C5a₁ receptor signalling ameliorates disease pathology in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Br.J.Pharmacol. 2017 PMID: 28128456
Fonseca Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 2009 PMID: 19561098
Jain The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 2013 PMID: 22924972
March Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 2004 PMID: 15044616