PLpro inhibitor 6

Name: PLpro inhibitor 6
Brand: Tocris Bioscience
SKU: 7357

Tocris Bioscience, part of Bio-Techne | Catalog # 7357

COA / SDS

SARS-CoV and SARS-CoV-2 PLpro inhibitor

Key Product Details

Description:	SARS-CoV and SARS-CoV-2 PLpro inhibitor
Chemical Name:	5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	346.43

View Full Technical Details for PLpro inhibitor 6

Technical Data
Citations

Biological Activity for PLpro inhibitor 6

PLpro inhibitor 6 is a SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC₅₀ values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC₅₀ values are 13.1 and 21 μM, respectively).

Technical Data for PLpro inhibitor 6

M. Wt	346.43
Formula	C₂₂H₂₂N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1093070-14-4
PubChem ID	44235889
InChi Key	KGPYBLOBHQLIET-OAHLLOKOSA-N
Smiles	C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(NC(C)=O)=C3)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PLpro inhibitor 6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.64	100
	ethanol	6.93	20

Preparing Stock Solutions for PLpro inhibitor 6

The following data is based on the product molecular weight 346.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.43 mL	28.87 mL
5 mM	0.58 mL	2.89 mL	5.77 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for PLpro inhibitor 6

References are publications that support the biological activity of the product.

Ratia A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18852458
Freitas Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect.Dis. 2020 PMID: 32428392