PIK 90

Name: PIK 90
Brand: Tocris Bioscience
SKU: 7902

Tocris Bioscience, part of Bio-Techne | Catalog # 7902

Citations (3)

COA / SDS

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

Key Product Details

Description:	Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation
Chemical Name:	N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	351.36

View Full Technical Details for PIK 90

Technical Data
Citations

Biological Activity for PIK 90

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC₅₀= 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC₅₀ = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.

Technical Data for PIK 90

M. Wt	351.36
Formula	C₁₈H₁₇N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	677338-12-4
PubChem ID	135398491
InChi Key	ZJAVHOMVDCMAMF-UHFFFAOYSA-N
Smiles	O=C(NC1=NC=2C(OC)=C(OC)C=CC2C3=NCCN13)C=4C=NC=CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PIK 90

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.51	10 with gentle warming

Preparing Stock Solutions for PIK 90

The following data is based on the product molecular weight 351.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.46 mL	142.30 mL	284.61 mL
0.5 mM	5.69 mL	28.46 mL	56.92 mL
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL

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References for PIK 90

References are publications that support the biological activity of the product.

Keymeulen To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J.Cell Biol. 2006 PMID: 16864657
Knight A pharmacological map of the PI3-K family defines a role for p110a in insulin signaling. Cell 2006 PMID: 16647110
Kishimoto Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nat.Protoc. 2022 PMID: 35978039
Fan A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 2006 PMID: 16697955