PIK 90

Product Description

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC₅₀ = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC₅₀ = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.

Solubility

Preparing Stock Solutions for PIK 90

The following data is based on the product molecular weight 351.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.46 mL	142.30 mL	284.61 mL
0.5 mM	5.69 mL	28.46 mL	56.92 mL
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Keymeulen To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J.Cell Biol. 2006 PMID: 16864657
• Knight A pharmacological map of the PI3-K family defines a role for p110a in insulin signaling. Cell 2006 PMID: 16647110
• Kishimoto Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nat.Protoc. 2022 PMID: 35978039
• Fan A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 2006 PMID: 16697955