PHT 427

Tocris Bioscience, part of Bio-Techne | Catalog # 4598

Dual Akt and PDK1 inhibitor; antitumor
Discontinued Product
4598 has been discontinued. View all Akt (Protein Kinase B) Inhibitors products.

Key Product Details

Description

Dual Akt and PDK1 inhibitor; antitumor

View all Akt (Protein Kinase B) Inhibitors »

Product Description

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Product Specifications

Molecular Weight

409.61

Formula

C20H31N3O2S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide

CAS Number

1191951-57-1

PubChem ID

44240850

InChI Key

BYWWNRBKPCPJMG-UHFFFAOYSA-N

SMILES

O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.96 100

Preparing Stock Solutions for PHT 427

The following data is based on the product molecular weight 409.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.41 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PHT 427

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PHT 427

For research use only

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