Phencyclidine hydrochloride

Name: Phencyclidine hydrochloride
Brand: Tocris Bioscience
SKU: 2557

Tocris Bioscience, part of Bio-Techne | Catalog # 2557

Citations (11)

COA / SDS

Non-competitive NMDA antagonist

Key Product Details

Description:	Non-competitive NMDA antagonist
Alternative Names:	PCP
Chemical Name:	1-(1-Phenylcyclohexyl)piperidine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	279.85

View Full Technical Details for Phencyclidine hydrochloride

Technical Data
Citations

Biological Activity for Phencyclidine hydrochloride

Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.

Technical Data for Phencyclidine hydrochloride

M. Wt	279.85
Formula	C₁₇H₂₅N.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	956-90-1
PubChem ID	13727
InChi Key	BUAJNGPDPGKBGV-UHFFFAOYSA-N
Smiles	N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Phencyclidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.19	40

Preparing Stock Solutions for Phencyclidine hydrochloride

The following data is based on the product molecular weight 279.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	8.93 mL	44.67 mL	89.33 mL
2 mM	1.79 mL	8.93 mL	17.87 mL
4 mM	0.89 mL	4.47 mL	8.93 mL
20 mM	0.18 mL	0.89 mL	1.79 mL

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Reconstitution Calculator

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References for Phencyclidine hydrochloride

References are publications that support the biological activity of the product.

Jin The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 1997 PMID: 9042584
Sharp Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 1997 PMID: 9203533
Linders Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 1993 PMID: 8355251