PHCCC

Tocris Bioscience, part of Bio-Techne | Catalog # 1027

COA / SDS

Potent group I mGlu antagonist

Key Product Details

Description:	Potent group I mGlu antagonist
Chemical Name:	N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	294.31

View Full Technical Details for PHCCC

Technical Data
Citations

Biological Activity for PHCCC

PHCCC is a group I metabotropic glutamate receptor antagonist (IC₅₀ ~ 3 μM); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu_4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.

Licensing Information

Sold for research purposes under license from Suntory Ltd.

Compound Libraries for PHCCC

PHCCC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PHCCC

M. Wt	294.31
Formula	C₁₇H₁₄N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	179068-02-1
PubChem ID	5866327
InChi Key	FPXPIEZPAXSELW-CYVLTUHYSA-N
Smiles	O=C(NC4=CC=CC=C4)C3(C2C3)OC1=CC=CC=C1/C2=N/O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PHCCC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.43	100

Preparing Stock Solutions for PHCCC

The following data is based on the product molecular weight 294.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.40 mL	6.80 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for PHCCC

References are publications that support the biological activity of the product.

Flor Positive allosteric modulators of metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization. Neuropharmacology
Marino Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc.Natl.Acad.Sci.USA 2003 PMID: 14593202
Annoura A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett.
Mao and Wang Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum. Synapse 2001 PMID: 11071713