PHA 543613 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3092
Potent and selective α7 nAChR agonist
Key Product Details
Description
Potent and selective α7 nAChR agonist
Product Description
PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
307.78
Formula
C15H17N3O2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
CAS Number
1586767-92-1
PubChem ID
56972222
InChI Key
YMTPSZUBRSEWNY-ZOWNYOTGSA-N
SMILES
O=C(C2=NC=C(OC=C3)C3=C2)N[C@@H]1C4CCN(CC4)C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.78 | 100 | |
| DMSO | 7.69 | 25 |
Preparing Stock Solutions
for PHA 543613 hydrochloride
The following data is based on the product molecular weight 307.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.25 mL | 32.49 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.50 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.25 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Faghih Allosteric modulators of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 2008 PMID: 18198823
- Acker Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg.Med.Chem.Letts. 2008 PMID: 1849016
- Wishka Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st J.Med.Chem. 2006 PMID: 16821801
Product Specific Notices for PHA 543613 hydrochloride
For research use only
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