PF 8380

Tocris Bioscience, part of Bio-Techne | Catalog # 4078

Potent autotaxin inhibitor
Discontinued Product
4078 has been discontinued. View all Autotaxin Inhibitors products.

Key Product Details

Description

Potent autotaxin inhibitor

View all Autotaxin Inhibitors »

Product Description

PF 8380 is a potent autotaxin inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Decreases leptin-induced MMP13 expression, in vitro. Orally available.

Product Specifications

Molecular Weight

478.33

Formula

C22H21Cl2N3O5

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate

CAS Number

1144035-53-9

PubChem ID

25265312

InChI Key

JMSUDQYHPSNBSN-UHFFFAOYSA-N

SMILES

O=C(C2=CC(OC(N4)=O)=C4C=C2)CCN1CCN(C(OCC3=CC(Cl)=CC(Cl)=C3)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.83 100

Preparing Stock Solutions for PF 8380

The following data is based on the product molecular weight 478.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.45 mL 20.91 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 8380

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 8380

For research use only

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