PF 514273

Name: PF 514273
Brand: Tocris Bioscience
SKU: 3676
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3676

(1)

Citations (57)

COA / SDS

High affinity and selective CB1 antagonist

Discontinued Product

3676 has been discontinued. View all Cannabinoid R1/CB1 Antagonists products.

Key Product Details

Description:	High affinity and selective CB₁ antagonist
Chemical Name:	2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	452.28

View Full Technical Details for PF 514273

Technical Data
Citations / Reviews (1)

Biological Activity for PF 514273

PF 514273 is a high affinity and selective CB₁ receptor antagonist (K_i values are 1 and > 10000 nM at CB₁ and CB₂ receptors respectively). Inhibits food intake in vivo following oral administration.

Technical Data for PF 514273

M. Wt	452.28
Formula	C₂₁H₁₇Cl₂F₂N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	851728-60-4
PubChem ID	11316919
InChi Key	FJMQJSUOOGOWBD-UHFFFAOYSA-N
Smiles	O=C2C1=NN(C4=CC=CC=C4Cl)C(C3=CC=C(Cl)C=C3)=C1OCCN2CC(C)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PF 514273

References are publications that support the biological activity of the product.

Dow Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of J.Med.Chem. 2009 PMID: 19351113

PF 514273

Tocris Bioscience, part of Bio-Techne | Catalog # 3676

Key Product Details

Biological Activity for PF 514273

Technical Data for PF 514273

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PF 514273

Product Documents for PF 514273

COA

Certificate of Analysis

SDS

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