PF 5006739

Name: PF 5006739
Brand: Tocris Bioscience
SKU: 6346

Tocris Bioscience, part of Bio-Techne | Catalog # 6346

COA / SDS

Potent CK1δ/ε inhibitor

Key Product Details

Description:	Potent CK1δ/ε inhibitor
Chemical Name:	4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	419.46

View Full Technical Details for PF 5006739

Technical Data
Citations

Biological Activity for PF 5006739

PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC₅₀ values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 5006739

PF 5006739 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 5006739

M. Wt	419.46
Formula	C₂₂H₂₂FN₇O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1293395-67-1
PubChem ID	51353555
InChi Key	XPWHRQHBPRSUAW-UHFFFAOYSA-N
Smiles	NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 5006739

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.95	100

Preparing Stock Solutions for PF 5006739

The following data is based on the product molecular weight 419.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for PF 5006739

References are publications that support the biological activity of the product.

Wager Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 2014 PMID: 25299732