PF 4800567 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4281

Selective casein kinase 1ε inhibitor
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Key Product Details

Description

Selective casein kinase 1ε inhibitor

View all Casein Kinase 1 Inhibitors »

Product Description

PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Product Specifications

Molecular Weight

396.27

Formula

C17H18ClN5O2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

CAS Number

1391052-28-0

PubChem ID

71751553

InChI Key

QZXZQMUZEHTFHD-UHFFFAOYSA-N

SMILES

NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.63 100

Preparing Stock Solutions for PF 4800567 hydrochloride

The following data is based on the product molecular weight 396.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.50 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 4800567 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 4800567 hydrochloride

For research use only

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